An enantiomer of atorvastatin that has little or no inhibitory activity against HMG-CoA reductase

(3S,5S)-Atorvastatin (sodium salt) – 1 mg

Brand:
Cayman
CAS:
1428118-38-0
Storage:
-20
UN-No:
Non-Hazardous - /

Atorvastatin (Item No. 10493) is an HMG-CoA reductase inhibitor (IC50 = 154 nM) that is effective against hypercholesterolemia and certain dyslipidemias.{18240,18241,18235} Atorvastatin can exist in four optical forms, with the 3R,5R enantiomer displaying the greatest activity against HMG-CoA reductase. (3S,5S)-Atorvastatin is an enantiomer of atorvastatin that has little or no inhibitory activity against HMG-CoA reductase.{29980} It also differs from other atorvastatin enantiomers in cytotoxicity, activation of the pregnane X receptor, and induction of cytochrome P450 isoforms.{29980,29981}  

 

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Description

An enantiomer of atorvastatin that has little or no inhibitory activity against HMG-CoA reductase

Formal name: 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, monosodium salt

Synonyms: 

Molecular weight: 580.6

CAS: 1428118-38-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism

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