A nicotinamide-nitric oxide ester with vasodilatory and cardioprotective effects; a potassium channel activator that targets vascular NDP-dependent K+ channels and cardiac ATP-sensitive K+ (KATP) channels (EC50 = 10 µM); an NO donor

Nicorandil – 50 mg

Brand:
Cayman
CAS:
65141-46-0
Storage:
-20
UN-No:
Non-Hazardous - /

Nicorandil is a nicotinamide-nitric oxide ester with vasodilatory and cardioprotective effects.{29851,29349} It is best known as a potassium channel activator that targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (EC50 = 10 µM).{29853} In addition to driving dilation of peripheral and coronary arterioles, K+ channel activation by nicorandil delays the induction of mitochondrial permeability transition in response to oxidative stress.{29852} Nicorandil can also act as a nitric oxide donor, increasing intracellular cGMP production leading to venodilation and pain suppression.{29851,29850}  

 

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Description

A nicotinamide-nitric oxide ester with vasodilatory and cardioprotective effects; a potassium channel activator that targets vascular NDP-dependent K+ channels and cardiac ATP-sensitive K+ (KATP) channels (EC50 = 10 µM); an NO donor, producing venodilation and pain suppression

Formal name: N-[2-(nitrooxy)ethyl]-3-pyridinecarboxamide

Synonyms:  2-Nicotinamidoethyl nitrate|SG-75

Molecular weight: 211.2

CAS: 65141-46-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ox Stress Reagents|NO Donors||Research Area|Cardiovascular System|Cardiovascular Diseases|Angina||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Cell Biology|Mitochondrial Biology

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