An inhibitor of DNA gyrase; inhibits the ATPase activity of DNA gyrase

Novobiocin (sodium salt) – 1 g

Brand:
Cayman
CAS:
1476-53-5
Storage:
-20
UN-No:
Non-Hazardous - /

Bacterial DNA gyrase is a heterodimeric type II topoisomerase that negatively supercoils circular double-stranded DNA. Novobiocin is a coumarin antibiotic, first isolated from Streptomyces species, that inhibits the ATPase activity of DNA gyrase.{27399} Its antibacterial activity arises from competitive inhibition of the ATPase reaction catalyzed by the GyrB subunit.{27399} In addition to permitting relaxation of negative supercoils, novobiocin has been used to generate positively supercoiled DNA.{29891} It also inhibits the chaperone activity of Hsp90 (IC50 = 700 mM).{29890,42532}  

 

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Description

An inhibitor of DNA gyrase; inhibits the ATPase activity of DNA gyrase, permitting relaxation of negative supercoils; has been used to generate positively supercoiled DNA; inhibits the chaperone activity of Hsp90 (IC50 = 700 mM),

Formal name: N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-benzamide, monosodium salt

Synonyms:  NSC 2382

Molecular weight: 634.6

CAS: 1476-53-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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