An alkaloid with diverse biological activities; completely inhibits tert-butyl hydroperoxide-induced lipid peroxidation and cell death in isolated rat hepatocytes at 200 µM; reduces copper- and peroxidase-induced LDL oxidation in vitro; reduces the number and area of aortic atherosclerotic lesions in LDLR-/- mice fed an atherogenic diet at 1 mg/animal per day; reduces carrageenan-induced paw edema in guinea pigs (ED50 = 43 mg/kg); reduces bacterial pyrogen-induced hyperthermia in rabbits at 60 mg/kg; increases the latency to myoclonic and clonic seizures in a mouse model of PTZ-induced seizures at 25 and 50 mg/kg; decreases electroshock-induced tonic hindlimb extension in mice

Boldine – 5 g

Brand:
Cayman
CAS:
476-70-0
Storage:
-20
UN-No:
Non-Hazardous - /

Boldine is an alkaloid that has been found in P. boldus and has diverse biological activities.{58104,58105,58106,58107} It completely inhibits tert-butyl hydroperoxide-induced lipid peroxidation and cell death in isolated rat hepatocytes when used at a concentration of 200 µM.{58104} Boldine reduces copper- and peroxidase-induced LDL oxidation in vitro in a concentration-dependent manner.{58105} In vivo, boldine (1 mg/animal per day) reduces the number and area of aortic atherosclerotic lesions in LDL receptor knockout (LDLR-/-) mice fed an atherogenic diet. It reduces carrageenan-induced paw edema in guinea pigs (ED50 = 43 mg/kg) and reduces bacterial pyrogen-induced hyperthermia in rabbits when administered at a dose of 60 mg/kg.{58106} Boldine (25 and 50 mg/kg) increases the latency to myoclonic and clonic seizures in a mouse model of seizures induced by pentylenetetrazole (PTZ; Item No. 18682).{58107} It also decreases electroshock-induced tonic hindlimb extension in mice.  

 

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Description

An alkaloid with diverse biological activities; completely inhibits tert-butyl hydroperoxide-induced lipid peroxidation and cell death in isolated rat hepatocytes at 200 µM; reduces copper- and peroxidase-induced LDL oxidation in vitro; reduces the number and area of aortic atherosclerotic lesions in LDLR-/- mice fed an atherogenic diet at 1 mg/animal per day; reduces carrageenan-induced paw edema in guinea pigs (ED50 = 43 mg/kg); reduces bacterial pyrogen-induced hyperthermia in rabbits at 60 mg/kg; increases the latency to myoclonic and clonic seizures in a mouse model of PTZ-induced seizures at 25 and 50 mg/kg; decreases electroshock-induced tonic hindlimb extension in mice

Formal name: 5,6,6aS,7-tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol

Synonyms:  (+)-(S)-Boldine|2,9-Dihydroxy-1,10-dimethoxyaporphine|NSC 65689

Molecular weight: 327.4

CAS: 476-70-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Seizure Disorders||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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