A potent inhibitor of actin incorporation into filaments; also increases the steady-state diffusion coefficients of filaments

Cytochalasin H – 1 mg

Brand:
Cayman
CAS:
53760-19-3
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin H is a potent inhibitor of actin incorporation into filaments.{25080,29763} Like cytochalasin D (Item No. 11330), it also increases the steady-state diffusion coefficients of filaments, suggesting that it stimulates filament shortening.{25080} Cytochalasin H suppresses the production of reactive oxygen species by stimulated human neutrophils, blocks endocytosis of CD59 in lymphocytes, and shows anti-angiogenic activity both in vitro and in vivo.{29673,29761,29762}  

 

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Description

A potent inhibitor of actin incorporation into filaments; also increases the steady-state diffusion coefficients of filaments, suggesting that it stimulates filament shortening

Formal name: (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(acetyloxy)-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-1H-cycloundec[d]isoindol-1-one

Synonyms:  17-Deoxo-21-acetylzygosporin D|Kodocytochalasin 1|Paspalin P1

Molecular weight: 493.6

CAS: 53760-19-3

Purity: ≥95%

Formulation: A lyophilisate

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Immunology & Inflammation|Innate Immunity

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