An inhibitor of EGFR and VEGFR tyrosine kinases (IC50s = 2

AEE788 – 10 mg

Brand:
Cayman
CAS:
497839-62-0
Storage:
-20
UN-No:
Non-Hazardous - /

AEE788 is an inhibitor of both epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinase family members.{31022} It can inhibit EGFR and VEGFR tyrosine kinases with IC50 values of 2, 6, 77, and 59 nM for EGFR, ErbB2, KDR, and FLT1, respectively.{31022} AEE788 demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines and can inhibit the proliferation of EGF- and VEGF-stimulated human umbilical vein endothelial cells.{31022} It also has been shown to have antitumor and anti-angiogenic activity in numerous animal models of cancer.{31022}  

 

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Description

An inhibitor of EGFR and VEGFR tyrosine kinases (IC50s = 2, 6, 77, and 59 nM for EGFR, ErbB2, KDR, and FLT1, respectively); demonstrates antitumor activity and anti-angiogenic activity in numerous in vitro and in vivo models

Formal name: 6-[4-[(4-ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Synonyms:  NVP-AEE788

Molecular weight: 440.6

CAS: 497839-62-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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