A selective

GDC-0068 – 5 mg

Brand:
Cayman
CAS:
1001264-89-6
Storage:
-20
UN-No:
Non-Hazardous - /

GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays.{30936} It is 620-fold selective for Akt over protein kinase A and has been shown to block Akt signaling selectively in cultured tumor cell lines characterized by activated Akt, halting cell cycle progression and reducing cell viability.{30936} In multiple tumor xenograft models, oral administration of GDC-0068 at 100 mg/kg/day can lead to delayed tumor growth and regression.{30936}  

 

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Description

A selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 (IC50s = 5, 18, and 8 nM, respectivley); blocks Akt signaling both in cultured tumor cell lines and tumor xenograft models

Formal name: (2S)-​(4-​chlorophenyl)​-​1-​[4-​[(5R,​7R)​-​6,​7-​dihydro-​7-​hydroxy-​5-​methyl-​5H-​cyclopentapyrimidin-​4-​yl]​-​1-​piperazinyl]​-​3-​[(1-​methylethyl)​amino]​-1-​propanone

Synonyms:  Ipatasertib|RG-7440

Molecular weight: 458

CAS: 1001264-89-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKB/Akt||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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