A potent inhibitor of the TGF-β1 receptor ALK5 (IC550 = 25 nM)

A-77-01 – 5 mg

Brand:
Cayman
CAS:
607737-87-1
Storage:
-20
UN-No:
Non-Hazardous - /

A-77-01 is a potent inhibitor of the TGF-β1 receptor ALK5 (IC50 = 25 nM).{31358} It has no effects on BMP-regulated transcriptional activity or MAPK pathways. A-77-01 efficiently prevents the growth inhibitory effects of TGF-β on lung epithelial Mv1Lu cells.{31358} It completely blocks phosphorylation of SMAD2 by TGF-β in human keratinocyte HaCaT cells at 1 µM. A-77-01 prevents morphological and gene expression changes characteristic of epithelial-to-mesenchymal transition in NMuMG cells treated with TGF-β.{31358}  

 

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Description

A potent inhibitor of the TGF-β1 receptor ALK5 (IC550 = 25 nM), blocking SMAD2 phosphorylation and growth inhibitory effects of TGF-β; prevents EMT transition in NMuMG cells treated with TGF-β

Formal name: 4-​[3-​(6-​methyl-​2-​​pyridinyl)​-​1H-​​pyrazol-​4-​yl]​-​quinoline

Synonyms: 

Molecular weight: 286.3

CAS: 607737-87-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Activin-like Kinases (ALKs)||Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer||Research Area|Cell Biology|Cell Signaling

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