An orally available inhibitor of microtubule polymerization (IC50 = ~3 µM) that blocks cell cycling at the G2-M phase

CYT997 – 10 mg

Brand:
Cayman
CAS:
917111-44-5
Storage:
-20
UN-No:
Non-Hazardous - /

CYT997 is an orally available inhibitor of microtubule polymerization (IC50 = ~3 µM) that blocks cell cycling at the G2-M phase, which leads to cell death.{30914} It is cytotoxic to a range of cancer cell lines (IC50s = 9-101 nM) and demonstrates antivascular activity in tumors both in vitro and in vivo.{30914,30915} CYT997 is being examined in clinical trials for efficacy against advanced solid tumors.{30916}  

 

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Description

An orally available inhibitor of microtubule polymerization (IC50 = ~3 µM) that blocks cell cycling at the G2-M phase, which leads to cell death; cytotoxic to a range of cancer cell lines (IC50s = 9-101 nM) and demonstrates antivascular activity in tumors both in vitro and in vivo

Formal name: N-ethyl-N’-[2-methoxy-4-[5-methyl-4-[[(1S)-1-(3-pyridinyl)butyl]amino]-2-pyrimidinyl]phenyl]-urea

Synonyms:  Lexibulin

Molecular weight: 434.5

CAS: 917111-44-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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