A potent inhibitor of CENP-E (Ki = 3.2 nM); causes mitotic cell cycle delay

GSK923295 – 50 mg

Brand:
Cayman
CAS:
1088965-37-0
Storage:
-20
UN-No:
Non-Hazardous - /

GSK923295 is a potent inhibitor of centromere-associated protein E (CENP-E; Ki = 3.2 nM), a kinesin motor protein involved in mitotic checkpoint signaling.{31966,31965} GSK923295 causes mitotic cell cycle delay, leading to apoptosis in various cancer cell lines.{31966} It induces apoptosis in cancer cells in mice bearing xenografts of COLO 205 cells.{31966,31965} GSK923295 can be used with AZ3146, an inhibitor of the spindle checkpoint kinase Mps1, to generate aneuploidy in cells.{31964}  

 

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Description

A potent inhibitor of CENP-E (Ki = 3.2 nM); causes mitotic cell cycle delay, leading to apoptosis in various cancer cell lines; induces apoptosis in cancer cells in mice bearing xenografts of COLO 205 cells

Formal name: 3-chloro-N-[(1S)-2-[[2-(dimethylamino)acetyl]amino]-1-[[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]methyl]ethyl]-4-(1-methylethoxy)-benzamide

Synonyms:  GSK923295A

Molecular weight: 592.1

CAS: 1088965-37-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis

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