An inhibitor of several ASK isoforms when given at a concentration of 10 µM

Bikinin – 50 mg

Brand:
Cayman
CAS:
188011-69-0
Storage:
-20
UN-No:
Non-Hazardous - /

The Arabidopsis shaggy-related kinases (ASKs) are plant kinases that are structurally similar to a Drosophila kinase, shaggy, which has key roles in development. ASKs are also similar to glycogen synthase kinase 3 isoforms, which are found in plants as well as animals. Bikinin is an inhibitor of several ASK isoforms when given at a concentration of 10 µM.{30819} After bikinin treatment, residual kinase activity was less than 10% for ASKα, γ, ε, ζ, η, ι, and 20% for ASKθ, while isoforms β and δ were not affected. Bikinin has little or no direct effect on a wide range of other kinases.{30819} By inhibiting ASKs, bikinin activates signaling induced by the brassinosteroid, brassinolide.{30819} Bikinin blocks the phosphorylation of SnRK2.3 by ASKη (also known as BIN2), upregulating signaling through abscisic acid (Item No. 10073).{30817} Bikinin has been used to study the role of ASK-modulated brassinosteroid signaling in wheat and in viral infection of plants.{30816,30820,30818}  

 

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Description

An inhibitor of several ASK isoforms when given at a concentration of 10 µM, leaving residual kinase activity at less than 10% for ASKα, γ, ε, ζ, η, ι, and 20% for ASKθ, without inhibiting isoforms β and δ; activates signaling induced by brassinosteroids

Formal name: 4-[(5-bromo-2-pyridinyl)amino]-4-oxo-butanoic acid

Synonyms: 

Molecular weight: 273.1

CAS: 188011-69-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Plant Biology

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