A selective inhibitor of late INa that has been shown to suppress experimentally induced arrhythmias in rabbit myocytes and hearts; inhibits A. sulcata toxin II–induced late INa in ventricular myocytes and isolated hearts (IC50s = 0.13 and 0.21 µM

GS967 – 100 mg

Brand:
Cayman
CAS:
1262618-39-2
Storage:
-20
UN-No:
Non-Hazardous - /

Inhibition of cardiac late sodium current (late INa) is a strategy to suppress arrhythmias and sodium-dependent calcium overload associated with myocardial ischemia and heart failure. GS967 is a selective inhibitor of late INa that has been shown to suppress experimentally induced arrhythmias in rabbit myocytes and hearts.{30900} It can inhibit A. sulcata toxin II–induced late INa in ventricular myocytes and isolated hearts with IC50 values of 0.13 and 0.21 µM, respectively.{30900} GS967 causes minimal inhibition of the delayed-rectifier potassium current nor does it affect L- or T-type calcium channel currents, sodium-calcium exchanger currents, or a panel of 162 receptors, ion channels, transporters, and enzymes.{30900}  

 

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Description

A selective inhibitor of late INa that has been shown to suppress experimentally induced arrhythmias in rabbit myocytes and hearts; inhibits A. sulcata toxin II–induced late INa in ventricular myocytes and isolated hearts (IC50s = 0.13 and 0.21 µM, respectively)

Formal name: 6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Synonyms: 

Molecular weight: 347.2

CAS: 1262618-39-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart|Arrhythmia

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