A chemical probe for PRMT5 that potently inhibits the PRMT5/MEP50 complex from methylating histone H4 (IC50 = 11 nM) in vitro; inhibits the symmetric arginine methylation of SmD3 (EC50 = 56 nM) in Z-138 cells

GSK591 – 5 mg

Brand:
Cayman
CAS:
1616391-87-7
Storage:
-20
UN-No:
Non-Hazardous - /

GSK591 is a chemical probe for protein arginine methyltransferase 5 (PRMT5) that potently inhibits the PRMT5/MEP50 complex from methylating histone H4 (IC50 = 11 nM) in vitro. GSK591 is selective for PRMT5 (up to 50 µM) relative to a panel of other methyltransferases. In Z-138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with an EC50 value of 56 nM. For more information on GSK591 please visit the Structural Genomics Consortium (SGC). The negative control, SGC2096, for GSK591 is also available exclusively through the SGC. You can submit a request to receive the negative control here.  

 

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Description

A chemical probe for PRMT5 that potently inhibits the PRMT5/MEP50 complex from methylating histone H4 (IC50 = 11 nM) in vitro; inhibits the symmetric arginine methylation of SmD3 (EC50 = 56 nM) in Z-138 cells

Formal name: 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyridinecarboxamide

Synonyms:  EPZ015866|GSK3203591

Molecular weight: 380.5

CAS: 1616391-87-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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