Description
An inhibitor of Nrf2-induced gene expression; reduces Nrf2-dependent expression of the genes encoding SOD1, HO-1, Trx, GCLM, and GPX2, as well as decreases GSH content in A549 cells at 5 µM; enhances tert-butyl hydroperoxide-induced A549 cell death; reduces tumor volume in an A549 mouse xenograft model at 50 mg/kg
Formal name: N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine
Synonyms:
Molecular weight: 379.4
CAS: 1030123-90-0
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals||Research Area|Cancer|Cell Death||Research Area|Cancer|Transcription Factors||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione
