A PPARα and PPARγ dual agonist; increases transcriptional activity of PPARα and PPARγ in a luciferase reporter assay in AC2F rat liver cells at 5 µM; reduces serum glucose

MHY908 – 5 mg

Brand:
Cayman
CAS:
1393371-39-5
Storage:
-20
UN-No:
Non-Hazardous - /

MHY908 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ that increases transcriptional activity of PPARα and PPARγ in a luciferase reporter assay in AC2F rat liver cells when used at a concentration of 5 µM.{29289} In vivo, MHY908 (3 mg/kg per day) reduces serum glucose, triglyceride, and insulin levels and improves hepatic steatosis by reducing hepatic triglyceride levels and lipid droplet accumulation in db/db mice and 20-month-old rats.{29289,37693} It reduces peroxynitrite and COX-2 levels, reactive oxygen species (ROS) production, and Akt phosphorylation in isolated kidney from 20-month-old rats when administered at a dose of 3 mg/kg.{37693} MHY908 inhibits mushroom tyrosinase (IC50 = 8.19 µM).{37692} It also inhibits increases in melanin content in α-melanocyte stimulating hormone-induced B16/F10 murine melanoma cells when used at a concentration of 10 µM.  

 

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Description

A PPARα and PPARγ dual agonist; increases transcriptional activity of PPARα and PPARγ in a luciferase reporter assay in AC2F rat liver cells at 5 µM; reduces serum glucose, triglyceride, and insulin levels and improves hepatic steatosis in db/db mice and 20-month-old rats at 3mg/kg; reduces peroxynitrite and COX-2 levels, ROS production, and Akt phosphorylation in 20-month-old rat kidney at 3 mg/kg; inhibits mushroom tyrosinase (IC50 = 8.19 µM); inhibits increases in melanin content in α-melanocyte stimulating hormone-induced B16/F10 murine melanoma cells at 10 µM.

Formal name: 2-[4-(5-chloro-2-benzothiazolyl)phenoxy]-2-methyl-propanoic acid

Synonyms: 

Molecular weight: 347.8

CAS: 1393371-39-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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