An inhibitor of hGIIA sPLA2 (IC50 = 9 nM)

LY315920 – 5 mg

Brand:
Cayman
CAS:
172732-68-2
Storage:
-20
UN-No:
Non-Hazardous - /

LY315920 is an inhibitor of human group IIA (hGIIA) secretory phospholipase A2 (sPLA2; IC50 = 9 nM).{3601} It also potently inhibits human GIIE and GX isoforms, as well as the corresponding mouse isoforms, but poorly inhibits other PLA2 enzymes.{3601,30706,30705,12332} LY315920 inhibits sPLA2-induced release of thromboxane A2 from isolated guinea pig lung bronchoalveolar lavage cells (IC50 = 0.79 µM).{30706} Intravenous or oral administration of LY315920 to transgenic mice expressing human sPLA2 inhibits serum sPLA2 activity in a dose-related manner over four hours.{30706}  

 

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Description

An inhibitor of hGIIA sPLA2 (IC50 = 9 nM), as well as mouse GIIA (mGIIA), hGIIE, mGIIE, hGX, and mGX PLA2s, but poorly inhibits other PLA2 enzymes; inhibits serum sPLA2 activity in transgenic mice expressing human sPLA2 when given either intravenously or orally

Formal name: 2-[[3-(2-amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]-acetic acid

Synonyms:  ​Varespladib

Molecular weight: 380.4

CAS: 172732-68-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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