A cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase

Diminutol – 5 mg

Brand:
Cayman
CAS:
361431-33-6
Storage:
-20
UN-No:
Non-Hazardous - /

Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 µM), to destabilize microtubules and disrupt mitosis.{29458} At 50 µM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization.{29458}  

 

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Description

A cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 µM), to depolymerize microtubules and disrupt mitosis

Formal name: (2R)-2-[[6-[(3-aminophenyl)thio]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

Synonyms:  NG72

Molecular weight: 386.5

CAS: 361431-33-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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