A pure enantiomer of lansoprazole that inhibits acid formation in isolated canine parietal cells with an IC50 value of 59 nM and inhibits the H+/K+-ATPase with an IC50 value of 4.2 µM

(R)-Lansoprazole – 100 mg

Brand:
Cayman
CAS:
138530-94-6
Storage:
-20
UN-No:
Non-Hazardous - /

Lansoprazole (Item No. 13627) is a proton pump inhibitor that irreversibly inactivates the H+/K+-stimulated ATPase pumps in parietal cells, inhibiting gastric acid secretion and increasing intragastric pH.{18250} It is a 1:1 racemic mixture of (R)-lansoprazole and (S)-lansoprazole, both of which are pharmacologically active.{29367} (R)-Lansoprazole is an enantiomerically pure form of lansoprazole. It can inhibit acid formation in isolated canine parietal cells with an IC50 value of 59 nM and inhibit the H+/K+-ATPase with an IC50 value of 4.2 µM.{29367}  

 

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Description

A pure enantiomer of lansoprazole that inhibits acid formation in isolated canine parietal cells with an IC50 value of 59 nM and inhibits the H+/K+-ATPase with an IC50 value of 4.2 µM

Formal name: 2-[(R)-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole

Synonyms:  (+)-Lansoprazole|T-168390|TAK-390

Molecular weight: 369.4

CAS: 138530-94-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience

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