An enantiomer of pramipexole that is ~100-fold less active than the (S) form as a dopamine receptor agonist; an antioxidant that targets mitochondria to prevent apoptosis

(R)-Pramipexole (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
104632-27-1
Storage:
-20
UN-No:
Non-Hazardous - /

Pramipexole (Item No. 11981) is an agonist of dopamine receptors that has applications in Parkinson’s disease and other disorders.{21783,21784,21785,21786} Pramipexole is usually available as a mixture of enantiomers, with the majority of the dopamine receptor-dependent activity resulting from the (S) form.{29401} (R)-Pramipexole is an enantiomer of pramipexole that is ~100-fold less active than the (S) form as a dopamine receptor agonist.{29401,29399} For this reason, it can be used as a negative control for the (S) form in the study of dopamine receptors. Both isoforms are antioxidants that target mitochondria to prevent apoptosis.{29401,29402,29398,29403} This cytoprotective effect of (R)-pramipexole, without dopaminergic side effects, suggests utility in amyotrophic lateral sclerosis.{29401,29400}  

 

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Description

An enantiomer of pramipexole that is ~100-fold less active than the (S) form as a dopamine receptor agonist; an antioxidant that targets mitochondria to prevent apoptosis

Formal name: 4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine, dihydrochloride

Synonyms:  (+)-Pramipexole|Dexpramipexole|KNS 760704|SND 919CL2X

Molecular weight: 284.2

CAS: 104632-27-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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