A cardenolide and aglycone constituent of digitoxin that elicits cardiac contraction and cardiotonic effects by inhibiting the Na+/K+ ATPase; inhibits protein synthesis and has been examined for use as an antitumor compound

Digitoxigenin – 10 mg

Brand:
Cayman
CAS:
143-62-4
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Digitoxigenin is a cardenolide and aglycone constituent of digitoxin, an extract from the foxglove plant, D. purpurea. It elicits cardiac contraction and cardiotonic effects by inhibiting the Na+/K+ ATPase via binding at the digitalis receptor site with nanomolar potency.{23988,29469} Digitoxigenin is highly cytotoxic, inhibiting Na+/K+ ATPase-dependent protein synthesis, and has been examined for use as an antitumor compound.{29470}  

 

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Description

A cardenolide and aglycone constituent of digitoxin that elicits cardiac contraction and cardiotonic effects by inhibiting the Na+/K+ ATPase; inhibits protein synthesis and has been examined for use as an antitumor compound

Formal name: (3β,5β)-3,14-dihydroxy-card-20(22)-enolide

Synonyms:  (+)-Digitoxigenin|Cerberigenin|Echujetin|Evonogenin|NSC 407806|Thevetigenin|Δ20:22-3,14,21-Trihydroxynorcholenic acid lactone

Molecular weight: 374.5

CAS: 143-62-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Heart|Myocardial Contractility

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