An HIV-1 integrase inhibitor; inhibits Dnp-stimulated ATPase activity of rat liver mitochondria and mitoplasts (IC50 = ~8 nM per mg of protein for both); inhibits ADP-stimulated respiration and the mitochondrial transport of ATP

Equisetin – 1 mg

Brand:
Cayman
CAS:
57749-43-6
Storage:
-20
UN-No:
Non-Hazardous - /

Equisetin is a fungal metabolite that has been isolated from Fusarium.{29275,29276} It inhibits HIV-1 integrase 3’ end-processing and strand transfer activities.{29277} Equisetin inhibits the ATPase activity of rat liver mitochondria and mitoplasts stimulated by 2,4-dinitrophenol (Dnp) in a concentration-dependent manner (IC50 = ~8 nM per mg of protein for both).{30486} It also inhibits ADP-stimulated respiration and the mitochondrial transport of ATP, inorganic phosphate, and succinate. Epiequisetin is phytotoxic and inhibits the germination of various seeds and growth of young seedlings.{41886}  

 

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Description

An HIV-1 integrase inhibitor; inhibits Dnp-stimulated ATPase activity of rat liver mitochondria and mitoplasts (IC50 = ~8 nM per mg of protein for both); inhibits ADP-stimulated respiration and the mitochondrial transport of ATP, inorganic phosphate, and succinate; phytotoxic

Formal name: (3E,5S)-5-(hydroxymethyl)-3-[hydroxy[(1S,2R,4aS,6R,8aR)-1,2,4a,5,6,7,8,8a-octahydro-1,6-dimethyl-2-(1E)-1-propen-1-yl-1-naphthalenyl]methylene]-1-methyl-2,4-pyrrolidinedione

Synonyms: 

Molecular weight: 373.5

CAS: 57749-43-6

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Antivirals|Integrase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Plant Biology

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