An NSAID that non-selectively inhibits human COX-1 and -2 with IC50 values of 0.35 and 0.82 µM

Tolmetin (sodium salt hydrate) – 25 g

Brand:
Cayman
CAS:
64490-92-2
Storage:
-20
UN-No:
Non-Hazardous - /

Tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human COX-1 and -2 with IC50 values of 0.35 and 0.82 µM, respectively.{8427} It also inhibits aldo-keto reductases (e.g., IC50 = 2.39 µM for human aldose reductase), a family of enzymes that catalyze the NADPH-dependent reduction of carbonyl groups in a number of important steroid, metabolic, and prostanoid molecules.{27311,29322}  

 

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Description

An NSAID that non-selectively inhibits human COX-1 and -2 with IC50 values of 0.35 and 0.82 µM, respectively; also inhibits aldo-keto reductases (e.g., IC50 = 2.39 µM for human aldose reductase)

Formal name: 1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid, monosodium, dihydrate

Synonyms: 

Molecular weight: 315.3

CAS: 64490-92-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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