A histamine H1 receptor antagonist (Ki = 10 nM); reverses acetyl-β-methylcholine-induced contraction of isolated rat tracheal strips; inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells; reduces severity of colitis and phospho-IκB kinase activation in a mouse model of DSS-induced colitis

Fexofenadine (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
153439-40-8
Storage:
-20
UN-No:
Non-Hazardous - /

Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM).{27483} It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine (Item No. 23092).{36897} Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells.{36898} Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250).  

 

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Description

A histamine H1 receptor antagonist (Ki = 10 nM); reverses acetyl-β-methylcholine-induced contraction of isolated rat tracheal strips; inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells; reduces severity of colitis and phospho-IκB kinase activation in a mouse model of DSS-induced colitis

Formal name: 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-benzeneacetic acid, monohydrochloride

Synonyms:  MDL 16455A

Molecular weight: 538.1

CAS: 153439-40-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis

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