A PDE5A inhibitor (IC50 = 574 nM) that prevents platelet aggregation by increasing cGMP levels and blocking the reuptake of adenosine via red blood cells; scavenges the free radicals that inactivate COX

Dipyridamole – 5 g

Brand:
Cayman
CAS:
58-32-2
Storage:
-20
UN-No:
Non-Hazardous - /

Dipyridamole is a phosphodiesterase 5A (PDE5A) inhibitor (IC50 = 574 nM) that prevents platelet aggregation by increasing cGMP levels and blocking the reuptake of adenosine via red blood cells.{23680,29326} It also scavenges the free radicals that inactivate cyclooxygenase, leading to the inhibition of platelet activation and thrombin generation.{23680} Dipyridamole has also been shown to inhibit PDE11A with an IC50 value of 370 nM and equilibrative nucleoside transporter 1 (ENT1) with a Ki value of 8.18 nM.{17520,29324} It inhibits replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero E6 cells when used at a concentration of 100 nM.{49690} Formulations containing dipyridamole in combination with aspirin (Item No. 70260) have been used to prevent stroke and other cardiovascular events.{19319}  

 

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Description

A PDE5A inhibitor (IC50 = 574 nM) that prevents platelet aggregation by increasing cGMP levels and blocking the reuptake of adenosine via red blood cells; scavenges the free radicals that inactivate COX, leading to the inhibition of platelet activation and thrombin generation; also inhibits PDE11A (IC50 = 370 nM) and ENT1 (Ki = 8.18 nM); inhibits replication of SARS-CoV-2 in Vero E6 cells at 100 nM

Formal name: 2,2’,2”,2”’-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-ethanol

Synonyms:  NSC 515776|NSC 619103

Molecular weight: 504.6

CAS: 58-32-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Cell Biology|Cell Signaling|cGMP Signaling||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Immunology & Inflammation|Pulmonary Diseases|COVID-19||Research Area|Infectious Disease|Viral Diseases|Coronaviruses

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