A coniferyl ester that acts as a partial agonist of TRPV1 (EC50 = 3.2 µM)

Capsiconiate – 1 mg

Brand:
Cayman
CAS:
946572-73-2
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Capsiconiate is a coniferyl ester that has been isolated from certain plants in the Solanaceae family, including plants in the genus Capsicum.{29501} It is structurally related to capsaicin (Item No. 92350), the primary heat- and pain-eliciting compound from the Capsicum pepper.{10293} Like capsaicin, capsiconiate is an agonist of the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.2 µM).{29501} However, the maximum response induced by capsiconiate through TRPV1 is only 20% of that of capsaicin, indicating that it’s a partial agonist of TRPV1.{29501}  

 

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Description

A coniferyl ester that acts as a partial agonist of TRPV1 (EC50 = 3.2 µM), eliciting only 20% of the maximum response induced by capsaicin

Formal name: 8-methyl-6E-nonenoic acid 3-(4-hydroxy-3-methoxyphenyl)-2E-propen-1-yl ester

Synonyms:  Coniferyl (E)-8-methyl-6-nonenoate

Molecular weight: 332.4

CAS: 946572-73-2

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Natural Products||Research Area|Neuroscience|Pain Research

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