A broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin; inhibits the survival and migration of cancer cells

Nifuroxazide – 1 g

Brand:
Cayman
CAS:
965-52-6
Storage:
-20
UN-No:
Non-Hazardous - /

Nifuroxazide is a broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin.{29335} Like other nitrofuran antibiotics, nifuroxazide is activated during metabolism by microbial nitroreductases.{29335} It has been shown to block quorum sensing in P. aeruginosa.{29336} Nifuroxazide also inhibits the survival and migration of cancer cells, suppressing tumor growth and metastasis in vivo, at least in part by inhibiting STAT3 (IC50 = 10 µM).{29334,29337}  

 

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Description

A broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin; inhibits the survival and migration of cancer cells, suppressing tumor growth and metastasis in vivo, at least in part by inhibiting STAT3 (IC50 = 10 µM)

Formal name: 4-hydroxy-benzoic acid, 2-[(5-nitro-2-furanyl)methylene]hydrazide

Synonyms: 

Molecular weight: 275.2

CAS: 965-52-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Nitrofurans||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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