6α-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cAMP accumulation in human thyroid slices and cells in a concentration dependent manner. However

6α-Prostaglandin I1 – 10 mg

Brand:
Cayman
CAS:
62777-90-6
Storage:
-20
UN-No:
Non-Hazardous - /

6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response.{11172} 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).{11183}  

 

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Description

6α-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cAMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response.{11172} 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).{11183}

Formal name: 6R,9α-epoxy-11α,15S-dihydroxy-prost-13E-en-1-oic acid

Synonyms:  5,6α-dihydro PGI2|6α-PGI1

Molecular weight: 354.5

CAS: 62777-90-6

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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