A selective PDK1 inhibitor (IC50 = ~10 nM) that even at 100-fold higher concentrations does not affect the activity of 93 other protein kinases

GSK2334470 – 25 mg

Brand:
Cayman
CAS:
1227911-45-6
Storage:
-20
UN-No:
Non-Hazardous - /

3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that plays an important role in growth factor signaling by phosphorylating and activating a group of kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC. GSK2334470 is an inhibitor of PDK1 (IC50 = ~10 nM) that even at 100-fold higher concentrations does not affect the activity of 93 other protein kinases, including that of 13 closely related AGC kinase family members.{29229} In HEK293 cells, 30 nM – 1 µM GSK2334470 suppresses T-loop phosphorylation and activation of SGK, S6K1, and RSK, as well as the activation of Akt.{29229}  

 

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Description

A selective PDK1 inhibitor (IC50 = ~10 nM) that even at 100-fold higher concentrations does not affect the activity of 93 other protein kinases, including that of 13 closely related AGC kinase family members; suppresses T-loop phosphorylation and activation of SGK, S6K1, and RSK, as well as the activation of Akt

Formal name: (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide

Synonyms: 

Molecular weight: 462.6

CAS: 1227911-45-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area

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