A potent

SGX523 – 10 mg

Brand:
Cayman
CAS:
1022150-57-7
Storage:
-20
UN-No:
Non-Hazardous - /

The hepatocyte growth factor receptor c-Met commonly shows elevated activity in several forms of cancer.{29341,29344} SGX523 is a potent, selective, ATP-competitive inhibitor that blocks the tyrosine kinase activity of c-Met with an IC50 value of 4 nM.{29341} It is over 1,000-fold selective for c-Met over a panel of other kinases.{29341} SGX523 is orally active and dose-dependently inhibits the growth of a variety of tumor xenografts in mice.{29341,29343} The effectiveness of SGX523 is enhanced when combined with other chemotherapeutic compounds, including inhibitors of EGFR.{29344,29345} SGX523 is metabolized, at least in part, by aldehyde oxidase, an enzyme that differs in activity across different species.{29342}  

 

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Description

A potent, selective, ATP-competitive inhibitor that blocks the tyrosine kinase activity of c-Met with an IC50 value of 4 nM

Formal name: 6-[[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-quinoline

Synonyms: 

Molecular weight: 359.4

CAS: 1022150-57-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling

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