An endogenous polyamine required for eukaryotic cell growth and protein synthesis; blocks inward rectifying K+ channels and acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site; scavenges free radicals to prevent DNA damage by ROS

Spermine – 1 g

Brand:
Cayman
CAS:
71-44-3
Storage:
-20
UN-No:
Non-Hazardous - 3259 / 8

Spermine is an endogenous polyamine synthesized from the reaction of spermidine (Item No. 14918) with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis.{27553,29231} Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site.{29232} Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.{29233}  

 

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Description

An endogenous polyamine required for eukaryotic cell growth and protein synthesis; blocks inward rectifying K+ channels and acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site; scavenges free radicals to prevent DNA damage by ROS

Formal name: N1,N4-bis(3-aminopropyl)-1,4-butanediamine

Synonyms:  1,5,10,14-Tetraazatetradecane|Gerontine|Musculamine|Neuridine|NSC 268508

Molecular weight: 202.3

CAS: 71-44-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Immunology & Inflammation||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|DNA/RNA Oxidative Damage||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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