An inhibitor of β-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARγ and PPARδ; blocks the recruitment of β-catenin and GRIP1 to PPARγ and PPARδ; selectively toxic to some carcinoma cell lines expressing the Wnt/β-catenin pathway

FH535 – 50 mg

Brand:
Cayman
CAS:
108409-83-2
Storage:
-20
UN-No:
Non-Hazardous - /

FH535 is an inhibitor of β-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARγ and PPARδ.{15982} At 15 µM, FH535 blocks the recruitment of β-catenin and GRIP1 to PPARγ and PPARδ.{15982} Presumably through these actions, FH535 is selectively toxic to some carcinoma cell lines expressing the Wnt/β-catenin pathway.{15982} FH535 is used to study the role of Wnt/β-catenin pathway in various cancer cell lines.{30755,30756,30757}  

 

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Description

An inhibitor of β-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARγ and PPARδ; blocks the recruitment of β-catenin and GRIP1 to PPARγ and PPARδ; selectively toxic to some carcinoma cell lines expressing the Wnt/β-catenin pathway

Formal name: 2,5-dichloro-N-(2-methyl-4-nitrophenyl)-benzenesulfonamide

Synonyms: 

Molecular weight: 361.2

CAS: 108409-83-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Cancer|Transcription Factors||Research Area|Cell Biology|Cell Signaling|Wnt Signaling

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