An LRRK2 inhibitor with IC50s = 1.28 and 1.85 nM for wild-type and G2019S mutant forms of LRRK2

CZC-54252 – 25 mg

Brand:
Cayman
CAS:
1191911-27-9
Storage:
-20
UN-No:
Non-Hazardous - /

CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50s = 1.28 and 1.85 nM for wild-type and G2019S mutant forms of LRRK2, respectively).{32555} It has been shown to protect against neuronal injury induced by Parkinson’s disease-related LRRK2-G2019S mutant activity in primary human neurons with an EC50 value of 1 nM.{32556}  

 

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Description

An LRRK2 inhibitor with IC50s = 1.28 and 1.85 nM for wild-type and G2019S mutant forms of LRRK2, respectively; protects against neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM)

Formal name: N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide

Synonyms: 

Molecular weight: 505

CAS: 1191911-27-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection

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