A selective

Afuresertib (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
1047645-82-8
Storage:
-20
UN-No:
Non-Hazardous - /

Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively.{30969} It preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation and various cell lines derived from hematologic malignancies with minimal effect on glucose homeostasis.{30969} Afuresertib demonstrates activity against multiple myeloma in both preclinical and clinical models.{30969,30970}  

 

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Description

A selective, orally bioavailable inhibitor of Akt1, 2, and 3 (Kis = 0.08, 2, and 2.6 nM, respectively); inhibits the proliferation of human cancer cell lines with Akt pathway activation and various cell lines derived from hematologic malignancies

Formal name: N-​[(1S)​-​2-​amino-​1-​[(3-​fluorophenyl)​methyl]​ethyl]​-​5-​chloro-​4-​(4-​chloro-​1-​methyl-​1H-​pyrazol-​5-​yl)​-2-​thiophenecarboxamide, monohydrochloride​

Synonyms:  GSK2110183B

Molecular weight: 463.8

CAS: 1047645-82-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKB/Akt||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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