Key Features Specially formulated Single-Use Docosahexaenoic Acid (peroxide free) for use in cell culture or other in vitro experiments Peroxide free and sealed under argon to maintain product integrity Each pack contains 10 single-use ampules (>1 ml fatty acid at 500 µg/ml in ethanol) Single-use docosahexaenoic acid (peroxide free) consists of 10 sealed ampules, each containing >1 ml of ethanolic solution of fatty acid at a concentration of 500 µg/ml. Peroxides were removed by silicic acid chromatography. The headspace in each ampule is purged with argon. Single-use polyunsaturated fatty acids (PUFAs) are intended for analytical and research applications where absence of oxidized adducts is desired. Ampules have been optimized for one-time use. For best results, use promptly after opening. Docosahexaenoic acid (Item No. 90310) is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. PUFAs, including docosahexaenoic acid, oxidize spontaneously on exposure to room air, yielding a complex mixture of fatty acid peroxides. Oxidation of PUFAs can be particularly problematic in samples stored in capped vials for prolonged periods, even at low temperatures. These single-use ampules are designed to circumvent this issue.
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An ethanolic solution in sealed ampules with the headspace purged with argon
Formal name: 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid
Synonyms: Single-Use Cervonic Acid (peroxide free)|Single-Use DHA (peroxide free)
Molecular weight: 328.5
CAS: 6217-54-5
Purity: ≥98%
Formulation: A solution in ethanol
Application|Mass Spectrometry||Product Type|Biochemicals|Lipids|Docosanoids||Product Type|Biochemicals|Lipids|Fatty Acids||Research Area|Lipid Biochemistry|Fatty Acids
The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
Available on backorder
The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
Available on backorder