A natural flavanone glycoside formed from naringenin and neohesperidose; undergoes extensive metabolism in the liver

Naringin – 25 g

Brand:
Cayman
CAS:
10236-47-2
Storage:
-20
UN-No:
Non-Hazardous - /

Naringenin (Item No. 14173) is a citrus-derived flavonoid that inhibits cytochrome P450 (CYP) 3A4 activity in human liver microsomes (IC50s = 139-188 μM).{18074,22311} Naringin is a natural flavanone glycoside formed from naringenin and neohesperidose. It undergoes extensive metabolism in the liver, giving rise to naringenin and other bioactive metabolites that have anti-oxidant, anti-inflammatory, and anti-apoptotic effects.{29091} Naringin is a weak inhibitor of CYP3A4, providing 14% inhibition at 200 µM.{22311} It suppresses apoptosis in neurons and increases the expression of neurotrophic factor in dopaminergic neurons, providing neuroprotection.{29092}  

 

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Description

A natural flavanone glycoside formed from naringenin and neohesperidose; undergoes extensive metabolism in the liver, giving rise to naringenin and other bioactive metabolites that have anti-oxidant, anti-inflammatory, and anti-apoptotic effects

Formal name: (2S)-7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  NSC 5548

Molecular weight: 580.5

CAS: 10236-47-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Immunology & Inflammation||Research Area|Neuroscience

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