A ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading

3-(4-Pyridyl)indole – 50 mg

Brand:
Cayman
CAS:
7272-84-6
Storage:
-20
UN-No:
Non-Hazardous - /

Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal.{17734,17735,17322} 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay.{29128} It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.{29128}  

 

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Description

A ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay; also inhibits ROCK-II and PRK2 with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency

Formal name: 3-(4-pyridinyl)-1H-indole

Synonyms:  Rho Kinase Inhibitor III|ROCK Inhibitor III|Rockout

Molecular weight: 194.2

CAS: 7272-84-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|ROCK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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