An indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I; cytotoxic to human lung adenocarcinoma

Rebeccamycin – 2.5 mg

Brand:
Cayman
CAS:
93908-02-2
Storage:
-20
UN-No:
Non-Hazardous - /

Rebeccamycin is an indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I.{25390,29155} It is cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC50s range from 0.4-98 µM), producing single-strand breaks in the DNA of these tumor cells.{29156}  

 

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Description

An indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I; cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC50s range from 0.4-98 µM)

Formal name: 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

Synonyms:  BRN 4732638|NSC 359079

Molecular weight: 570.4

CAS: 93908-02-2

Purity: ≥99%

Formulation: A lyophilisate

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|Topoisomerase

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