Description
An alkaloid originally found to have antimicrobial actions; both 5-LO and COX-2 (IC50s = 600 and 64 nM, respectively); suppresses angiogenesis, blocking signaling through VEGFR2 at the level of ERK1/2 signaling; prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity
Formal name: indolo[2,1-b]quinazoline-6,12-dione
Synonyms: NSC 349447
Molecular weight: 248.2
CAS: 13220-57-0
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity
