An alkaloid originally found to have antimicrobial actions; both 5-LO and COX-2 (IC50s = 600 and 64 nM

Tryptanthrin – 1 mg

Brand:
Cayman
CAS:
13220-57-0
Storage:
-20
UN-No:
Non-Hazardous - /

Tryptanthrin is an alkaloid tryptophan derivative originally isolated from various plants and found to have antimicrobial actions. Among its many actions in cells, it inhibits both 5-lipoxygenase and cyclooxygenase-2 (IC50s = 600 and 64 nM, respectively).{29112,29109} Tryptanthrin suppresses angiogenesis in vivo and blocks signaling through VEGFR2 at the level of ERK1/2 signaling in vitro.{29110} It also prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity.{29111}  

 

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Description

An alkaloid originally found to have antimicrobial actions; both 5-LO and COX-2 (IC50s = 600 and 64 nM, respectively); suppresses angiogenesis, blocking signaling through VEGFR2 at the level of ERK1/2 signaling; prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity

Formal name: indolo[2,1-b]quinazoline-6,12-dione

Synonyms:  NSC 349447

Molecular weight: 248.2

CAS: 13220-57-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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