A sulforaphane analog found in cruciferous vegetables that demonstrates potent anti-inflammatory effects; doubles the phase II enzyme quinone reductase activity in mouse hepatoma cells at 1.7 µM; inhibits degradation of IκBα

Berteroin – 10 mg

Brand:
Cayman
CAS:
4430-42-6
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Berteroin is a sulforaphane (Item No. 10496) analog found in cruciferous vegetables including Chinese cabbage, rucola salad leaves, and mustard oil.{29282} At 1.7 µM, it has been shown to double the phase II enzyme quinone reductase activity in mouse hepatoma cells.{21908} Berteroin exerts anti-inflammatory activity in LPS-stimulated RAW 264.7 macrophages, inhibiting degradation of IκBα, as well as NF-κB p65 translocation to the nucleus and DNA binding activity.{29282} It also suppresses IRAK degradation and phosphorylation of TAK1, p38 MAPK, ERK1/2, and Akt.{29282}  

 

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Description

A sulforaphane analog found in cruciferous vegetables that demonstrates potent anti-inflammatory effects; doubles the phase II enzyme quinone reductase activity in mouse hepatoma cells at 1.7 µM; inhibits degradation of IκBα, NF-κB p65 translocation to the nucleus, IRAK degradation, and phosphorylation of TAK1, p38 MAPK, ERK1/2, and Akt in LPS-stimulated RAW 264.7 macrophages

Formal name: 1-isothiocyanato-5-(methylthio)-pentane

Synonyms:  5-Methylthiopentyl isothiocyanate

Molecular weight: 175.3

CAS: 4430-42-6

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity

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