A major inactive metabolite of clopidogrel that is used as a reference standard for quantitative analysis of clopidogrel metabolism

Clopidogrel Carboxylic Acid (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
144750-42-5
Storage:
-20
UN-No:
Non-Hazardous - /

Clopidogrel (Item No. 13657) is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM).{19256,19258} Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity.{19259} An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite.{29027} Clopidogrel carboxylic acid is a major inactive metabolite of clopidogrel. Most (85%) of circulating clopidogrel is hydrolyzed by esterases to this carboxylic acid form.{29027} This inactive metabolite can be used as a reference standard for quantitative analysis of clopidogrel metabolism.{29028}  

 

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Description

A major inactive metabolite of clopidogrel that is used as a reference standard for quantitative analysis of clopidogrel metabolism

Formal name: αS-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetic acid, monohydrochloride

Synonyms:  SR26334

Molecular weight: 344.3

CAS: 144750-42-5

Purity: ≥95%

Formulation: A crystalline solid

Application||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis

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