A bulky purine analog that acts as a selective

3MB-PP1 – 5 mg

Brand:
Cayman
CAS:
956025-83-5
Storage:
-20
UN-No:
Non-Hazardous - /

In several model organisms, the generation of conditional analog-sensitive kinase alleles has been developed as a chemical genetic strategy wherein a mutational enlargement of the ATP-binding site enables a protein kinase to interact with bulky ATP analogs.{28954,28952} Thus, a generic bulky ATP analog can competitively inhibit the activity of the mutant kinase, without interfering with the function of wild-type kinases whose ATP-binding pockets remain too small to accommodate the bulky analog. 3MB-PP1 is a bulky purine analog that acts as a selective, ATP-competitive, analog-sensitive polo-like kinase 1 (Plk1) allele inhibitor.{28953} At 10 µM, it can block mitotic progression in cells expressing analog-sensitive Plk1 alleles and has been used to selectively sensitize Plk1 to small-molecule inhibitors.{28952,28953}  

 

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Description

A bulky purine analog that acts as a selective, ATP-competitive, analog-sensitive Plk1 allele inhibitor; blocks mitotic progression in cells expressing analog-sensitive Plk1 alleles at 10 µM and selectively sensitizes Plk1 to small-molecule inhibitors

Formal name: 1-(1,1-dimethylethyl)-3-[(3-methylphenyl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Synonyms: 

Molecular weight: 295.4

CAS: 956025-83-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Plks||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Cycle

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