An ATP-competitive B-Raf inhibitor (IC50 = 10 nM; Kd = 2.4 nM) that inhibits cell proliferation both in B-Raf mutated and wild-type melanoma cell lines

L-779,450 – 5 mg

Brand:
Cayman
CAS:
303727-31-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

L-779,450 is an ATP-competitive B-Raf inhibitor (IC50 = 10 nM; Kd = 2.4 nM) that displays >7, >30, and >70-fold selectivity over p38α, GSK3β, and Lck, respectively.{31626} It has been shown to inhibit cell proliferation both in B-Raf mutated and wild-type melanoma cell lines, as well as to enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in these cells.{31625}  

 

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Description

An ATP-competitive B-Raf inhibitor (IC50 = 10 nM; Kd = 2.4 nM) that inhibits cell proliferation both in B-Raf mutated and wild-type melanoma cell lines

Formal name: 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]-phenol

Synonyms:  Raf Kinase Inhibitor IV

Molecular weight: 347.8

CAS: 303727-31-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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