An inhibitor of Ras-induced malignant transformation that prevents anchorage-independent growth of oncogene transformed fibroblasts; blocks Ras/Rac-induced membrane ruffling in REF-52 fibroblasts (5-25 µM) with little effect on Ras-induced ERK and JNK kinase activity

SCH 51344 – 10 mg

Brand:
Cayman
CAS:
171927-40-5
Storage:
-20
UN-No:
Non-Hazardous - /

SCH 51344 is a pyrazolo-quinoline derivative that inhibits Ras-induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts.{28957} At 5-25 µM, it has been shown to dose-dependently block Ras/Rac-induced membrane ruffling in REF-52 fibroblasts with little effect on Ras-induced ERK and JNK kinase activity.{28958} SCH 51344 is also reported to be a potent inhibitor of human mutT homolog MTH1, a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (Kd = 49 nM).{28959}  

 

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Description

An inhibitor of Ras-induced malignant transformation that prevents anchorage-independent growth of oncogene transformed fibroblasts; blocks Ras/Rac-induced membrane ruffling in REF-52 fibroblasts (5-25 µM) with little effect on Ras-induced ERK and JNK kinase activity,,

Formal name: 2-[2-[(6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]-ethanol

Synonyms:  Ras/Rac Transformaton Blocker

Molecular weight: 316.4

CAS: 171927-40-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Migration & Metastasis

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