A diselenide-bridged amino acid that has both anti- and pro-oxidant actions; can be reduced by low molecular thiols and disulfide reductases to selenocysteine; has cytostatic effects in a range of cancer cell types

L-Selenocystine – 1 g

Brand:
Cayman
CAS:
29621-88-3
Storage:
-20
UN-No:
De Minimis - 3283 / 6.1

L-Selenocystine is a diselenide-bridged amino acid that may be confused with selenocysteine (Sec), which is a rare amino acid featuring a single selenium atom. L-Selenocystine is a redox-active selenium compound that has both anti- and pro-oxidant actions.{29926,29925} This compound can be reduced by low molecular thiols and disulfide reductases to Sec. It is reduced to Sec by mammalian thioredoxin reductase (apparent Km = 6.0 µM), and this property can be used to assay thioredoxin reductase activity.{29925,29924} L-Selenocystine induces an unfolded protein response, ER stress, and large cytoplasmic vacuolization in HeLa cells and has cytostatic effects in a range of cancer cell types.{29925,29927}  

 

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Description

A diselenide-bridged amino acid that has both anti- and pro-oxidant actions; can be reduced by low molecular thiols and disulfide reductases to selenocysteine; has cytostatic effects in a range of cancer cell types

Formal name: 3,3′-diselenobis-L-alanine

Synonyms:  Seleno-L-cystine

Molecular weight: 334.1

CAS: 29621-88-3

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Thioredoxin

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