An antiepileptic compound; positive allosteric modulator of GABAA receptors that potentiates GABA-mediated activation of α3 subunit-containing GABAA receptors; inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices; inhibits LDH1 and LDH4 at 500 µM

Stiripentol – 10 mg

Brand:
Cayman
CAS:
49763-96-4
Storage:
-20
UN-No:
Non-Hazardous - /

Stiripentol is a third-generation antiepileptic compound.{28852} It is a positive allosteric modulator of GABAA receptors, potentiating GABA-mediated activation to a greater extent in receptors expressing α3 subunits and to a lower extent in those containing β1 or ε subunits.{48495} It also inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices.{28852,48496} Stiripentol (500 µM) inhibits lactate dehydrogenase (LDH), blocking both lactate-to-pyruvate and pyruvate-to-lactate conversions by human LDH1 and LDH5.{28811} Formulations containing stiripentol have been used in the adjunctive treatment of seizures associated with Dravet syndrome.  

 

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Description

An antiepileptic compound; positive allosteric modulator of GABAA receptors that potentiates GABA-mediated activation of α3 subunit-containing GABAA receptors; inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices; inhibits LDH1 and LDH4 at 500 µM

Formal name: 1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol

Synonyms:  BCX 2600

Molecular weight: 234.3

CAS: 49763-96-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Neuroscience|Seizure Disorders

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