An inhibitor of sphingolipid synthesis and aminotransferases; inhibits bacterial SPT 100 times more potently than D-cycloserine; inhibits SPT activity up to 86% in a dose-dependent manner in mouse brain microsomes following administration of doses ranging from 25-200 mg/kg; inhibits SPT in rabbit aorta and several aminotransferases in vitro and in vivo in rat; inhibits the growth of M. tuberculosis through branched chain aminotransferase inactivation

L-Cycloserine – 25 mg

Brand:
Cayman
CAS:
339-72-0
Storage:
-20
UN-No:
Non-Hazardous - /

L-Cycloserine is a potent inhibitor of serine palmitoyl transferase (SPT), the first enzyme in the sphingolipid synthesis pathway.{39381} It inhibits bacterial SPT activity by 80% at a concentration of 25 µM, which is 100 times more potent than D-cycloserine (Item No. 22194). L-Cycloserine inhibits SPT activity up to 86% in a dose-dependent manner in microsomes prepared from mouse brain following administration of doses ranging from 25-200 mg/kg. It also inhibits SPT in rabbit aorta and several aminotransferases in vitro and in vivo in rat.{39382,39383} L-Cycloserine inhibits the growth of M. tuberculosis through branched chain aminotransferase inactivation, and it does so more rapidly and potently than D-cycloserine (MICs = 0.3 and 2.3 µg/ml, respectively).{39380}  

 

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Description

An inhibitor of sphingolipid synthesis and aminotransferases; inhibits bacterial SPT 100 times more potently than D-cycloserine; inhibits SPT activity up to 86% in a dose-dependent manner in mouse brain microsomes following administration of doses ranging from 25-200 mg/kg; inhibits SPT in rabbit aorta and several aminotransferases in vitro and in vivo in rat; inhibits the growth of M. tuberculosis through branched chain aminotransferase inactivation, and it does so more rapidly and potently than D-cycloserine (MICs = 0.3 and 2.3 µg/ml, respectively),

Formal name: 4S-amino-3-isoxazolidinone

Synonyms:  L-4-amino 3-Isoxazolidinone|(-)-Cycloserine|(S)-Cycloserine|Levcycloserine

Molecular weight: 102.1

CAS: 339-72-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis||Research Area|Lipid Biochemistry|Sphingolipids

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