A potent and selective inhibitor of neutrophil elastase (IC50 = 44 nM); effective in vivo

Sivelestat (sodium salt hydrate) – 5 mg

Brand:
Cayman
CAS:
201677-61-4
Storage:
-20
UN-No:
Non-Hazardous - /

Sivelestat is a potent and selective inhibitor of neutrophil elastase (IC50 = 44 nM).{29354} It is without effect on a panel of related proteases.{29354} Sivelestat is effective in vivo, blocking elastase-dependent acute lung injury induced by intratracheal administration of LPS.{29354,29356} Elastase inhibitors, including sivelestat, have clinical utility in protecting against direct or indirect lung injury, with or without concomitant sepsis.{29353,29355,23600}  

 

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Description

A potent and selective inhibitor of neutrophil elastase (IC50 = 44 nM); effective in vivo, blocking elastase-dependent acute lung injury

Formal name: 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester 2,2-dimethyl-propanoic acid, monosodium salt, tetrahydrate

Synonyms:  LY544349|ONO-5046

Molecular weight: 528.5

CAS: 201677-61-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock

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