A fungal metabolite that inhibits DGAT activity

Amidepsine A – 2.5 mg

Brand:
Cayman
CAS:
169181-28-6
Storage:
-20
UN-No:
Non-Hazardous - /

Diacylglycerol acyltransferases (DGATs) catalyze the final step in triglyceride synthesis. DGAT-1 deficient mice demonstrate a phenotype that is protective against the development of diet-induced obesity or insulin resistance, implicating the actions of this enzyme in the development of such metabolic disorders. Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits DGAT activity (IC50 = 10.2 µM in rat liver microsomes).{29217} It inhibits triacylglycerol formation in Raji cells with an IC50 value of 15.5 µM.{29217}  

 

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Description

A fungal metabolite that inhibits DGAT activity, preventing triacylglycerol formation (IC50s = 10.2 and 15.5 µM in rat liver microsomes and Raji cells, respectively

Formal name: 2,4-dimethoxy-6-methyl-benzoic acid, 4-[[4-[[(1-carboxyethyl)amino]carbonyl]-3-hydroxy-5-methylphenoxy]carbonyl]-3-hydroxy-5-methylphenyl ester

Synonyms:  FO-2942A

Molecular weight: 567.5

CAS: 169181-28-6

Purity: ≥95%

Formulation: A powder

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Acyltransferases||Research Area|Endocrinology & Metabolism

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