An autophagy inhibitor

Spautin-1 – 50 mg

Brand:
Cayman
CAS:
1262888-28-7
Storage:
-20
UN-No:
Non-Hazardous - /

Spautin-1 is an autophagy inhibitor, inducing cell death in human breast cancer Bcap-37 cells grown in glucose-free media (EC50 = ~1.25 µM).{29038} It does not significantly affect the viability of Bcap-37 cells grown in complete media. Spautin-1 promotes the degradation of Vps34 PI3K complex by inhibiting the deubiquitinating enzymes USP10 and USP13 (IC50s = 0.58 and 0.69 µM, respectively).{29038} It is used to elucidate the role of autophagy in cellular processes.{29040,29041} Spautin-1 has also been used to demonstrate roles for autophagy in viral infection.{29039,29037}  

 

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Description

An autophagy inhibitor, inducing cell death in human breast cancer Bcap-37 cells grown in glucose-free media (EC50 = ~1.25 µM); promotes the degradation of Vps34 PI3K complex by inhibiting the deubiquitinating enzymes USP10 and USP13 (IC50s = 0.58 and 0.69 µM, respectively)

Formal name: 6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine

Synonyms: 

Molecular weight: 271.3

CAS: 1262888-28-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer|Autophagy||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases

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